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Flow of ISF into bulk CSF sampled from the cisterna magna accounted for 60-75% of efflux from midbrain however only 10-15% of efflux from caudate nucleus or internal capsule. RISA was concentrated in the subarachnoid area, relative to bulk CSF, in sleeves of adventitial tissue surrounding pericerebral arteries, possibly accounting for the low recovery of isotope from bulk CSF. ISF drainage charges (mul X g mind-1 X min-1) estimated for the three injection sites had been 0.18, 0.19, and 0.29, respectively. Pathways of interstitial fluid (ISF) drainage from different regions of mind. Studies have been carried out in anesthetized rats comparing dynamics. From the subarachnoid area, some fluid drained through olfactory nerve sheaths to retropharyngeal lymph nodes. Rates of drainage from brain and circulation into cerebrospinal fluid (CSF) had been estimated from the efflux from brain and influx into CSF of radioiodinated albumin (RISA) following microinjection into caudate nucleus, inner capsule, or midbrain: pathways of circulate by the subarachnoid area and into lymph had been traced from the distribution of horseradish peroxidase and/or Evans blue-labeled albumin after injection into mind.
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